Time to Relax: Mechanical Stress Release Guides Stem Cell Responses
نویسندگان
چکیده
منابع مشابه
Gadd45a regulates hematopoietic stem cell stress responses in mice.
Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, following 5-fluorouracil treatment, Gadd45a(-/-) HSCs exhibited a faster recove...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2016
ISSN: 1934-5909
DOI: 10.1016/j.stem.2016.01.020